Lupinelli began to establish himself in 1986 with the show Harvè Harvè, directed by Maria Martinelli and with Danilo Conti. Later, he worked with Marcello Aliprandi on the film Quando non c’era ancora i Beatles, produced by Rai 3. In 1989 he performed La mia casa, by Heinrich Böll, with Eugenio Sideri.
In 1990 he began his involvement with Teatro delle Albe. He is a member of Ravenna Teatro with whom he performed Incantati, All’inferno, Perindherion, I Polacchi, Sogno di una notte di mezza estate, I Refrattari and Salmagundi, written and directed by Marco Martinelli and performed in major Italian and European theatres.
In 1991 Lupinelli founded the non-scuola (non-school) with Marco Martinelli. In 1997 he started working with disabled people in Ravenna where he created Woyzech. He inaugurated a collaboration with the Associazione Pl.e.ia.di in 1999 in Lerici (SP), making his debut in Hallo Kattrin, after Bertholt Brecht’s Mother Courage, in June 2000. In 2001 he created Ella by H. Achternbusch, with Eugenio Sideri and continued his involvement with the Associazione Pl.e.ia.di with the staging of Uno Studio per Marat-Sade, based on Peter Weiss’s Marat-Sade in 2004. In 2007 the project landed in the province of Livorno and led to the production of MARAT, produced by Armunia and Casaarsa Teatro in collaboration with the cultural Association Pl.e.ia.di in Lerici (SP) and the Cooperativa Sociale Nuovo Futuro in Rosignano Marittimo (LI).
In 2007 Lupinelli left Teatro delle Albe and together with Elisa Pol founded their company Nerval Teatro and the Laboratorio Permanente, a socially inclusive theatre project for the disabled in Rosignano Marittimo (LI). In the capacity of both actor and director he has created the shows Fuoco Nero and Magnificat by Antonio Moresco, Appassionatamente– from the writings of Werner Schwab, 4.48 Psychosis by Sarah Kane, Le Presidentesse (First Ladies) by Werner Schwab, Carezze– with Roberto Abbiati, Canelupo Nudo– by Rita Frongia and directed by Claudio Morganti, Ma perché non dici mai niente– monologue by Lucia Calamaro, and Le Lacrime amare di Petra von Kant (The bitter tears of Petra von Kant) by R.W. Fassbinder.
He has directed important works received at the national level for Laboratorio Permanente such as MARAT (2007), Hamlet! Ovvero l’incontro mancato (2009), Appassionatamente (2010 Schwab Project), Che cosa sono le nuvole (2012 Pasolini Project), Attraversamenti, Winnie and Sinfonia Beckettiana (2015-2018 Beckett Project), DOPPELGÄNGER/Chi incontra il suo doppio, muore (2021) with dancer Filippo Porro and disabled actor Francesco Mastrocinque. Directed in collaboration with the company Abbondanza Bertoni, the piece was awarded the prize for Best Dance Show at the Premio Ubu 2021 festival.